Activated p300 acetyltransferase activity modulates aortic valvular calcification with osteogenic transdifferentiation and downregulation of Klotho

Article ID	Journal	Published Year	Pages	File Type
5605213	International Journal of Cardiology	2017	9 Pages	PDF

Abstract

Activated HAT activity of p300 modulates AV calcification through osteogenic transdifferentiation of VICs with Klotho modulation. P300 inhibition is a potential therapeutic target for AV calcification.

Keywords

TGF TNF High phosphate TNAP CAVD retinoid-X receptor RXR VDRE VDR EGR-1 ECM P300 IκB NF-κB MMP VIC HDAC ERK MAPK Osteogenesis calcific aortic valve disease transforming growth factor Aortic valve Valve interstitial cell Valvular interstitial cells vitamin D response element tumor necrosis factor nuclear factor kappa-light-chain-enhancer of activated B cells Phosphate Extracellular matrix matrix metalloproteinase inhibitor of kappa B Histone acetyltransferase histone deacetylase early growth response-1 mitogen-activated protein kinase HAT Aortic valve calcification Klotho extracellular signal-regulated kinase

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Activated p300 acetyltransferase activity modulates aortic valvular calcification with osteogenic transdifferentiation and downregulation of Klotho

Authors

Shao-Jung Li, Yu-Hsun Kao, Cheng-Chih Chung, Wei-Yu Chen, Wan-li Cheng, Yi-Jen Chen,