Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5615095 | Journal of Clinical Lipidology | 2017 | 21 Pages |
Abstract
The mechanisms underlying statin-associated muscle symptoms (SAMS) are not understood. Mitochondrial dysfunction and atrogin-1 activation are among the leading possible explanations for SAMS. Interestingly, metformin can enhance mitochondrial function and may affect atrogin-1 expression. Therefore, we sought to perform a systematic search of the literature to explore the relationship among statins, metformin, and SAMS.
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Authors
Ossama MD, Beth PhD, Amanda MS, Gregory MA, Paul D. MD,