Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5615335 | Journal of Clinical Lipidology | 2017 | 39 Pages |
Abstract
Heterozygous carriers with a defective lipoprotein lipase allele are less insulin sensitive and have increased plasma levels of nonesterified fatty acids and triglycerides. The heterozygous N291S carriers also have a distinct plasma metabolomic signature, which may serve as a diagnostic tool for deficient lipoprotein lipase activity and as a marker of lipid-induced insulin resistance.
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Authors
Sofia Mikkelsen PhD, Jesper PhD, Harald PhD, Vibeke PhD, Andreas James Thestrup MD, PhD, Aleksander Bill MD, Mads MD, PhD, Henning MD, PhD, Kurt MD, PhD, Nils Joakim PhD,