Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5615805 | The Journal of Heart and Lung Transplantation | 2017 | 25 Pages |
Abstract
Our study demonstrates that VAD support elicits IgG Nabs reactive to apoptotic cells and oxidized epitopes. These findings further support broad and non-specific B-cell activation by VAD, resulting in IgG sensitization. Moreover, the association of serum IgG Nabs levels with development of PGD suggests a possible role for these antibodies in the inflammatory reaction accompanying this complication.
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Authors
Sarah B. PhD, Kevin J. MD, Peter J. MD, Feifan PhD, MSc, Matthew P. MSc, Kortney J. BSc, Debanjana PhD, Elena R. MD, George MD, Yoshifumi MD, PhD, Susan W. MD, Maryjane A. MD, MSc, Veli K. MD, MSc, Paolo C. MD, Donna M. MD, P. Christian MD, PhD,