| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5616217 | The Journal of Thoracic and Cardiovascular Surgery | 2017 | 17 Pages |
Abstract
Our study suggests that NANOG is highly expressed in TAD aortic wall and VSMCs. Increased NANOG promotes VSMCs phenotype switch by directly up-regulating OPN through binding to its promoter region.
Keywords
OPNNanog homeoboxMMP2NANOGα-SMAVSMCqRT-PCRSM22αOsteopontinUltravioletAortic Dissectionα-smooth muscle actinchromatin immunoprecipitationTADTerminal deoxynucleotidyl transferase dUTP nick end labelingTUNELthoracic aortic dissectionSmooth muscle cellVascular smooth muscle cellmatrix metalloproteinase 2quantitative real-time polymerase chain reactionCHiP
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Authors
Zhao MD, Yang MD, Zhi-Gang MD, Hao MD, Yang MD, Zhi-Yun MD,