| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5616241 | The Journal of Thoracic and Cardiovascular Surgery | 2017 | 13 Pages |
Abstract
Gata4 administration reduces postinfarct ventricular fibrosis and improves ventricular function in a rat coronary ligation model, potentially as a result of Gata4-mediated downregulation of the profibrotic mediator Snail.
Keywords
ICMqPCRGATA4GFPαSMAGMThpfHDAC2qRT-PCRmesenchymal-epithelial transitionα-smooth muscle actinchromatin immunoprecipitationLeft ventricularanalysis of varianceANOVAEMTbase pairSnailFibrosisMEThigh-power fieldMyofibroblastHistone deacetylase 2quantitative reverse transcription polymerase chain reactionquantitative polymerase chain reactiongreen fluorescent proteinCHiPejection fractionEpithelial-mesenchymal transition
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Authors
Megumi MD, PhD, Vivek P. PhD, Deepthi MS, Lina PhD, Jaya Pratap MS, Jianchang MD, PhD, Todd K. MD,