| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5616279 | The Journal of Thoracic and Cardiovascular Surgery | 2017 | 20 Pages |
Abstract
We successfully established a novel, feasible rat model of pulmonary hypertension due to left heart diseases by generating left atrial stenosis. Although pulmonary hypertension was moderate, the pulmonary hypertension due to left heart diseases model rats demonstrated characteristic intrapulmonary venous arterialization and should be used to further investigate the mechanism of pulmonary hypertension due to left heart diseases.
Keywords
PCNALHDPVSTGFPDE-5IQRPDELASPAHProliferating Cell Nuclear Antigensmooth muscle actinendothelinRight ventricularleft heart diseasetransforming growth factorpulmonary vein stenosisSMALeft atriumpulmonary veinSOCPulmonary arteryHeart rateVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)PhosphodiesterasePulmonary arterial hypertensioninterquartile rangeRat modelheart failurePulmonary hypertension
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Authors
Yoshitaka MD, Takashi MD, PhD, Fumie MD, Toru MD, PhD, Yoichiro MD, PhD, Hiroyuki MD, PhD, Susumu MD, PhD,