Layered smooth muscle cell-endothelial progenitor cell sheets derived from the bone marrow augment postinfarction ventricular function

Article ID	Journal	Published Year	Pages	File Type
5616380	The Journal of Thoracic and Cardiovascular Surgery	2017	10 Pages	PDF

Abstract

The bone marrow-derived, spatially arranged SMC-EPC bi-level cell sheet is a novel, multilineage cellular therapy obtained from a translationally practical source. Interactions between SMCs and EPCs augment mature neovascularization, limit adverse remodeling, and improve ventricular function after myocardial infarction.

Keywords

ECM MSC DMEM FBS SMC EPC Dulbecco's modified Eagle's medium Myocardial infarction smooth muscle actin MRI Regeneration Left ventricular Magnetic resonance imaging SMA fetal bovine serum Stem cells Mesenchymal stem cells Smooth muscle cells Endothelial progenitor cells LAD Extracellular matrix Tissue engineering Neovascularization Cell sheet left anterior descending coronary artery

Related Topics

Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine

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Layered smooth muscle cell-endothelial progenitor cell sheets derived from the bone marrow augment postinfarction ventricular function

Authors

Yasuhiro MD, PhD, Andrew B. MD, PhD, Jeffrey E. MD, Jay B. BS, Michael S. BS, Amanda N. BS, Bryan B. BE, Masashi MD, PhD, Shigeru MD, PhD, Yoshiki MD, PhD, Y. Joseph MD,