Pericardial interstitial cell senescence responsible for pericardial structural remodeling in idiopathic and postsurgical constrictive pericarditis

Article ID	Journal	Published Year	Pages	File Type
5616383	The Journal of Thoracic and Cardiovascular Surgery	2017	14 Pages	PDF

Abstract

These findings suggest that senescent cells have characteristics promoting pericardial structural remodeling, but further work is needed to establish causation.

Keywords

ECM MMP DMEM qPCR MCP MGP SASP T/S PIC SA-β-gal Dulbecco's modified Eagle's medium senescence-associated β-galactosidase Structural remodeling tumor necrosis factor-α TIMP TNF-α Senescence-associated secretory phenotype Extracellular matrix matrix metalloproteinase BMP Tissue inhibitors of metalloproteinase quantitative polymerase chain reaction monocyte chemoattractant protein Matrix Gla protein Bone morphogenetic protein Constrictive pericarditis Senescence

Related Topics

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Pericardial interstitial cell senescence responsible for pericardial structural remodeling in idiopathic and postsurgical constrictive pericarditis

Authors

Lin MD, Xin MD, Guanxin MD, Zhiyun MD, Dejun BD, Fanglin MD, Xiaohong MD,