| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5616472 | The Journal of Thoracic and Cardiovascular Surgery | 2017 | 10 Pages |
Abstract
Functional reduction of sodium-potassium-chloride co-transporter by genetic or pharmacologic treatment to inhibit sodium-potassium-chloride co-transporter resulted in lower severity of acute lung injury induced by ischemia-reperfusion. Sodium-potassium-chloride co-transporter may present a promising target for therapeutic interventions in a clinical setting.
Keywords
NF-κBOSR1MIP-2PAPIKKIκBPVPPBSIκB kinaseMAPKW/DAcute lung injuryIschemia–reperfusion injuryAliSPAKischemia–reperfusionBALFtumor necrosis factor-αPulmonary arteryTNF-αnuclear factor-kappaBnuclear factor-κBPulmonary artery pressuremacrophage inflammatory protein-2Bronchoalveolar lavage fluidPhosphate-buffered salineinhibitor of NF-κBmicrovascular permeabilitywild-typebody weightlung weightmitogen activated protein kinase
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Authors
Chou-Chin MD, PhD, Chung-Kan MD, PhD, Shih-En MD, PhD, Hsueh-Ju MS, PhD, Sung-Sen MD, PhD, Chin-Pyng MD, PhD, Kun-Lun MD, PhD,