Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury

Failure of peripheral vascular interventions remains the single greatest challenge in management of vascular disease, with failure rates approaching 50% or greater within 2 years for many interventions. In contrast to the currently available cytotoxic drugs used on vascular devices that delay vessel healing, novel endogenous “proresolving” lipid mediators (such as resolvin D1) have potential to reduce neointimal hyperplasia by accelerating homeostasis. This study provides proof-of-concept for local perivascular delivery of proresolving agents to improve the healing response after acute vascular injury.