The regulatory role of smooth muscle 22 on the proliferation of aortic smooth muscle cells participates in the development of aortic dissection

In the population of China, the prevalence of aortic dissection (AD) is predicted to increase. Vascular smooth muscle cell pathological proliferation has been proven to play a role in AD development and vascular remodeling. This study addresses the role of smooth muscle 22 in mediating vascular smooth muscle cell proliferation, which is regulated by cellular calcium concentration. This study will help illuminate the pathological mechanism of aortic diseases and provide a new insight in research of smooth muscle 22 biological behavior and as a potential therapeutic agent for treatment of AD.