Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5617997 | Journal of Vascular Surgery | 2017 | 10 Pages |
Abstract
This preliminary study introduces the use of an allogeneic, cell-free, small-diameter vascular graft derived from the rolled human amniotic membrane. With this approach, graft diameter and wall thickness can be modulated to create conduits of specified dimensions. The ultimate goal is for the graft to integrate with native vasculature, allowing subsequent growth potential. Future work is needed to evaluate long-term remodeling and viability; however, in vivo investigation provides evidence that the layered scaffold can both mechanically withstand the stress of surgical implantation into native vasculature and subsequently support infiltration and early remodeling by host cell populations during 4 weeks.
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Authors
Salma PhD, Leslie A. Goldberg, Kerri A. PhD, Demaretta S. MD, Scott A. MD, PhD, Peter S. PhD,