Systemic inflammation as a predictor of clinical outcomes after lower extremity angioplasty/stenting

Endovascular intervention for lower extremity peripheral arterial disease is increasing exponentially, but short-term patency rates remain at 50% to 60%. This study used a high-throughput molecular strategy to define preprocedural and early postprocedural alterations in inflammatory signatures for patients at risk for early intervention failure. A number of promising proteomic markers and gene expression clusters were identified, specifically implicating pathways involving leukocyte extravasation, cellular migration, and cell-cycle signaling. This new knowledge enables personalized medicine by using this information in critical decision making before the intervention or by intervening early postprocedure to re-engineer a patient's course to a favorable outcome.