Fibroblast growth factor and vascular endothelial growth factor play a critical role in endotheliogenesis from human adipose-derived stem cells

Endothelial dysfunction is a primary mediator of vascular disease and critical limb ischemia. Treatment of this disease state is limited by available conduit and the inherent thrombogenicity of bypass grafts. Development of phenotypically and functionally similar endothelial cells from adipose-derived stem cells may allow for the creation of vascular conduits that are readily available and provide increased patency rates. Our study differentiated a cell line from human adipose that could be manipulated into endothelial cells that exhibit characteristics of endothelial cells, providing further information to already existing literature.