| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5618679 | Molecular Metabolism | 2017 | 10 Pages |
Abstract
These data indicate that ADAMTS5 plays a functional role in development of BAT and browning of WAT. Hence, selective targeting of ADAMTS5 could provide a novel therapeutic strategy for treatment/prevention of obesity and metabolic diseases.
Keywords
ECMADAMTS5β3-ARADAMTSTLGBATHFD%ID/gcAMP responsive element-binding proteinCREBUcp1Adipose tissueWAT, White adipose tissuebrown adipose tissueBrowningThermogenesisBeigehigh-fat dietsubcutaneousExtracellular matrixSUVObesitystandardized uptake valueuncoupling protein 1WATtotal lesion glycolysisGONGonadal
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Authors
Dries Bauters, Mathias Cobbaut, Lotte Geys, Johan Van Lint, Bianca Hemmeryckx, H. Roger Lijnen,