| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5618707 | Molecular Metabolism | 2017 | 25 Pages |
Abstract
Nrg4 exerts pleiotropic beneficial effects on energy balance and glucose and lipid metabolism to ameliorate obesity-associated metabolic disorders. Biologic therapeutics based on Nrg4 may improve both type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) in patients.
Keywords
COANAFLDG-protein coupled receptor 120UCP-1NALFDFGF21GPR120eWATBATHFDTNFαIL-6BMPsAdipokineinterleukin-6Adipose tissueWAT, White adipose tissuebrown adipose tissueDiabetesnon-alcoholic fatty liver diseaseTransgenicTAG یا triacylglycerols triglyceridetumor necrosis factor αhigh-fat dietfibroblast growth factor 21knockoutwild typeuncoupling protein 1bone morphogenetic proteinsbrown fatWAT
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Authors
Zhimin Chen, Guo-Xiao Wang, Sara L. Ma, Dae Young Jung, Hyekyung Ha, Tariq Altamimi, Xu-Yun Zhao, Liang Guo, Peng Zhang, Chun-Rui Hu, Ji-Xin Cheng, Gary D. Lopaschuk, Jason K. Kim, Jiandie D. Lin,