| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5622447 | Alzheimer's & Dementia | 2016 | 9 Pages |
Abstract
The effect of amyloid positivity on brain metabolism is regionally specific, and APOE ε4 status substantially modulates regional glucose uptake in these regions. The APOE ε4 allele may cause earlier emergence of clinical symptoms in AD via a mechanism that influences regional metabolic demand in specifically those regions where p-tau deposition is known to occur earliest.
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Authors
Andrea C. Bozoki, Monica Zdanukiewicz, David C. Zhu, Alzheimer's Disease Neuroimaging Initiative Alzheimer's Disease Neuroimaging Initiative,