| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5622729 | Alzheimer's & Dementia | 2014 | 10 Pages |
BackgroundType 2 diabetes (T2D) is associated with increased risk of dementia. The prospective longitudinal Israel Diabetes and Cognitive Decline study aims at identifying T2D-related characteristics associated with cognitive decline.MethodsSubjects are population-based T2D 65+, initially cognitively intact. Medical conditions, blood examinations, and medication use data are since 1998; cognitive, functional, demographic, psychiatric, DNA, and inflammatory marker study assessments were conducted every 18Â months. Because the duration of T2D reflects its chronicity and implications, we compared short (0-4.99Â years), moderate (5-9.99), and long (10+) duration for the first 897 subjects.ResultsThe long duration group used more T2D medications, had higher glucose, lower glomerular filtration rate, slower walking speed, and poorer cognitive functioning. Duration was not associated with most medical, blood, urine, and vital characteristics.ConclusionsTracking cognition, with face-to-face evaluations, exploiting 15Â years of historical detailed computerized, easily accessible, and validated T2D-related characteristics may provide novel insights into T2D-related dementia.
