Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5622970 | Alzheimer's & Dementia | 2014 | 9 Pages |
Abstract
These results suggest for the first time that LOAD risk variants at CR1 may influence memory endophenotypes in blacks. In addition, the CLU LOAD-protective variant may confer enhanced memory in whites. Although these results would not remain significant after stringent corrections for multiple testing, they need to be considered in the context of the LOAD associations with which they have biological consistency. They also provide estimates for effect sizes on memory endophenotypes that could guide future studies. The detection of memory effects for these variants in clinically normal subjects, implies that these LOAD risk loci might modify memory prior to clinical diagnosis of AD.
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Authors
Otto Pedraza, Mariet Allen, Kyle Jennette, Minerva Carrasquillo, Julia Crook, Daniel Serie, V. Shane Pankratz, Ryan Palusak, Thuy Nguyen, Kimberly Malphrus, Li Ma, Gina Bisceglio, Rosebud O. Roberts, John A. Lucas, Robert J. Ivnik, Glenn E. Smith,