| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5623063 | Alzheimer's & Dementia | 2013 | 7 Pages |
Abstract
Greater ICV, that is, premorbid brain size, seems to protect against clinical deterioration in the face of AD-related brain atrophy in aMCI. The results support the theory of a compensatory role of brain reserve in contrast to a neuroprotective role. The protective effects of morphologic reserve seem to be limited to early clinical AD; once a certain threshold of neurodegenerative burden is passed, a larger premorbid brain no longer offers an advantage in this context.
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Authors
Liang-Hao Guo, Panagiotis Alexopoulos, Stefan Wagenpfeil, Alexander Kurz, Robert Perneczky, Alzheimer's Disease Neuroimaging Initiative Alzheimer's Disease Neuroimaging Initiative,