Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5623685 | Alzheimer's & Dementia | 2016 | 10 Pages |
IntroductionThe impact of blood pressure on brain volumes may be time-dependent or pattern-dependent.MethodsOf 1678 participants from the Atherosclerosis Risk in Communities Neurocognitive Study, we quantified the association between measures and patterns of blood pressure over three time points (â¼24 or â¼15Â years prior and concurrent with neuroimaging) with late life brain volumes.ResultsHigher diastolic blood pressure â¼24Â years prior, higher systolic and pulse pressure â¼15Â years prior, and consistently elevated or rising systolic blood pressure from â¼15Â years prior to concurrent with neuroimaging, but not blood pressures measured concurrent with neuroimaging, were associated with smaller volumes. The pattern of hypertension â¼15Â years prior and hypotension concurrent with neuroimaging was associated with smaller volumes in regions preferentially affected by Alzheimer's disease (e.g., hippocampus: â0.27 standard units, 95% CI: â0.51, â0.03).DiscussionHypertension 15 to 24Â years prior is relevant to current brain volumes. Hypertension followed by hypotension appears particularly detrimental.