| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5624180 | Alzheimer's & Dementia | 2012 | 8 Pages |
Abstract
The positive correlation between sAPPα and sAPPβ challenges the hypothesis that AD is caused by an imbalance of the α- and β-secretase APP proteolysis through competing mechanisms. Moreover, the differences in CSF levels of sAPPα and sAPPβ between male and female patients with AD may reflect a “sexual dimorphism” in the activity of the two APP processing pathways in AD.
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Authors
Panagiotis Alexopoulos, Amalia Tsolakidou, Francesco Roselli, Anila Arnold, Timo Grimmer, Christine Westerteicher, Maria Rosaria Leante, Hans Förstl, Paolo Livrea, Alexander Kurz, Robert Perneczky,