| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5624285 | Alzheimer's & Dementia | 2014 | 9 Pages |
Abstract
Although cognitive aging patterns are similar in APOE ε4 carriers and noncarriers, preclinical AD is characterized by a significant ε4 gene dose effect that impacts memory and is detectable longitudinally. Preclinical neuropsychological testing strategies should emphasize memory-sensitive measures and longitudinal design.
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Authors
Richard J. Caselli, Dona E.C. Locke, Amylou C. Dueck, David S. Knopman, Bryan K. Woodruff, Charlene Hoffman-Snyder, Rosa Rademakers, Adam S. Fleisher, Eric M. Reiman,