Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5624685 | Alzheimer's & Dementia | 2008 | 7 Pages |
Abstract
Segregation and RNA analyses showed that the g.102delC mutation, previously reported, causes FTD in the Karolinska family. Our findings add further support to the significance of GRN in FTD etiology and the presence of modifying genes, which emphasize the need for further studies into the mechanisms of clinical heterogeneity. However, the results already call for attention to the complexity of predictive genetic testing of GRN mutations.
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Authors
Huei-Hsin Chiang, Lina Rosvall, Jesper Brohede, Karin Axelman, Behnosh F. Björk, Inger Nennesmo, Tiina Robins, Caroline Graff,