Original articleFrequency specific patterns of resting-state networks development from childhood to adolescence: A magnetoencephalography study

ObjectiveThe present study investigated frequency dependent developmental patterns of the brain resting-state networks from childhood to adolescence.MethodMagnetoencephalography (MEG) data were recorded from 20 healthy subjects at resting-state with eyes-open. The resting-state networks (RSNs) was analyzed at source-level. Brain network organization was characterized by mean clustering coefficient and average path length. The correlations between brain network measures and subjects' age during development from childhood to adolescence were statistically analyzed in delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), and beta (12-30 Hz) frequency bands.ResultsA significant positive correlation between functional connectivity with age was found in alpha and beta frequency bands. A significant negative correlation between average path lengths with age was found in beta frequency band.ConclusionsThe results suggest that there are significant developmental changes of resting-state networks from childhood to adolescence, which matures from a lattice network to a small-world network.