Les formes frontales de maladie d'Alzheimer

The frontal variant also known as behavioral and/or dysexecutive variant of Alzheimer's disease (AD) is a poorly understood and poorly defined entity. Patients present clinical features of behavioral disorders or executive disorders or both. However, the few descriptive studies also highlight worse memory scores than in the behavioral variant of frontotemporal degeneration, which is the main differential diagnosis. Patients with this variant are younger than people with AD and experience more rapid disease progression. There is some dissociation between the clinical frontal presentation and imaging or neuropathology findings that do not always suggest specific involvement of the frontal lobes. These inconsistencies need to be explored further with prospective studies that could also provide consensus criteria.