Topical application of ointment containing 0.5% green tea catechins suppresses tongue oxidative stress in 5-fluorouracil administered rats

Article ID	Journal	Published Year	Pages	File Type
5637910	Archives of Oral Biology	2017	35 Pages	PDF

Abstract

Topical application of ointment containing 0.5% green tea catechins could prevent tongue oxidative stress in 5-FU administered rats, via up-regulation of the Nrf2 signaling pathway.

Keywords

NF-κB 5-FU Nrf2 WBC RBC 8-OHdG 8-hydroxydeoxyguanosine keap1 ROS interleukin Oxidative stress Tongue Chemotherapy Antioxidant capacity nuclear factor-κB nuclear factor erythroid 2-related factor 2 5-fluorouracil Oral mucositis Hematoxylin and Eosin Kelch-like ECH-associated protein 1 Green tea catechin white blood cell red blood cell Reactive oxygen species

Related Topics

Health Sciences Medicine and Dentistry Dentistry, Oral Surgery and Medicine

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Topical application of ointment containing 0.5% green tea catechins suppresses tongue oxidative stress in 5-fluorouracil administered rats

Authors

Hisataka Miyai, Takayuki Maruyama, Takaaki Tomofuji, Toshiki Yoneda, Tetsuji Azuma, Hirofumi Mizuno, Yoshio Sugiura, Terumasa Kobayashi, Daisuke Ekuni, Manabu Morita,