Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5640146 | Journal of Cranio-Maxillofacial Surgery | 2017 | 27 Pages |
Abstract
Perineural invasion (PNI) is a widely recognized indicator of poor prognosis in oral cancer patients, strongly correlating with aggressive tumor behavior, disease recurrence, and increased morbidity and mortality. Elective neck dissection could be an indicator in improving neck control in PNI-positive patients, while the addition of adjuvant postoperative radiotherapy may not significantly improve survival rates. Various molecular markers have been correlated with perineural tumor spread, but further investigations are required before targeting PNI as part of advanced cancer therapies.
Keywords
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Dentistry, Oral Surgery and Medicine
Authors
Ioannis Chatzistefanou, Joshua Lubek, Konstantinos Markou, Robert A. Ord,