Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5640217 | Journal of Cranio-Maxillofacial Surgery | 2017 | 7 Pages |
The aim of this study was to evaluate preoperative ultrasound criteria to detect lymph node (LN) cervical metastasis in patients with clinically node-negative neck (cN0) oral cavity squamous cell carcinoma (OCSCC). A prospective, single-center, observational study was conducted in 90 patients undergoing cancer excision with or without elective neck dissection (END) between 2005 and 2012. A surgeon and an experienced radiologist performed preoperative cervical ultrasonography in all cases. The primary objective was to obtain an a priori sensitivity of 90% and specificity >50% in cN0 OCSCC staging. The sonographic criteria for LN assessment were as follows: number; neck levels; clusters; aspect; heterogeneity; longitudinal diameter (L); transverse diameter (T); L/T ratio; and combination in series or in parallel of T and L/T ratio. The gold standard for comparison was the LN histological identification of metastasis after END or the occurrence in the follow-up at least 36 months. Statistically significant sonographic criteria in univariate analysis (PÂ <Â 0.05) were as follows: multilevel lymph nodes, T diameter >6.5Â mm, and the combination TÂ >Â 6.5Â mm or L/TÂ <Â 1.3 ratio; and in multivariate logistic regression analysis were (PÂ <Â 0.05): combination TÂ >Â 6.5Â mm and L/TÂ <Â 1.3 ratio, LN in level II, and moderately-poorly differentiated OCSCC. By using selected sonographic criteria, ultrasound can be a valid preoperative diagnostic method to optimize staging cervical metastasis and to help decide about neck dissection.