Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5641695 | Journal of Oral and Maxillofacial Surgery | 2017 | 16 Pages |
Abstract
This pilot study shows that a relatively high frequency of CRGAs (37.5%) can be identified in CGCLs by use of CGP. Furthermore, 25% of CGCLs analyzed had somatic mutations predicted to activate the mitogen-activated protein kinase signaling pathway, suggesting it may be a driver of the aggressive behavior of these lesions. On the basis of this study, genomic profiling of a larger cohort of CGCLs to validate these observations, as well as correlate mutations with aggressive versus nonaggressive biological behavior and therapeutic responses, appears warranted.
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Authors
Brett DMD, MD, Heidi DO, Julia MD, PhD, Laurie PhD, David MD, Christopher DDS, MD,