Programmed death ligand 1 (PD-L1) expression and tumor microenvironment: Implications for patients with oral precancerous lesions

Article ID	Journal	Published Year	Pages	File Type
5642677	Oral Oncology	2017	8 Pages	PDF

Abstract

Our results indicate that PD-L1-expressing dysplastic epithelial and recruited subepithelial cells in oral precancerous legions may evade the host immune system, and that the inhibition of PD-1/PD-L1 pathway may potentially prevent malignant transformation of oral precancerous legions as well as can treat advanced cancers.

Keywords

PD-1 PD-L1 CIS CD163 H&E sin TIL TAM Oral cancer tumor-infiltrating lymphocyte Oral leukoplakia Programmed death ligand 1 Macrophage Tumor-associated macrophage Programmed death 1 Squamous intraepithelial neoplasia Hematoxylin and Eosin Carcinoma in situ

Related Topics

Health Sciences Medicine and Dentistry Dentistry, Oral Surgery and Medicine

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Programmed death ligand 1 (PD-L1) expression and tumor microenvironment: Implications for patients with oral precancerous lesions

Authors

Takahiro Yagyuu, Kinta Hatakeyama, Mitsuhiko Imada, Miyako Kurihara, Yumiko Matsusue, Kazuhiko Yamamoto, Chiho Obayashi, Tadaaki Kirita,