Sentinel Node Lymphoscintigraphy in High-risk Cutaneous Squamous Cell Carcinoma

In the present prospective analysis, sentinel lymph node mapping resulted in upstaging in 13% of the patients. The tumor depth was independently associated with an increased risk of nodal involvement. Given the association between a depth of tumor invasion of ≥ 4 mm and occult nodal disease in cutaneous squamous cell carcinoma, sentinel lymph node mapping could be considered an integral part of surgical staging for patients with high-risk features.