| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5646473 | Journal of Allergy and Clinical Immunology | 2017 | 47 Pages |
Abstract
Our study demonstrated that CXCL16-CXCR6 mediates CD8+ T-cell skin trafficking under oxidative stress in patients with vitiligo. The CXCL16 expression in human keratinocytes induced by ROS is, at least in part, caused by unfolded protein response activation.
Keywords
NF-κBHSPA5CXCR6CXCL16shRNADAPIeIF2αUPRXBP14′-6-diamidino-2-phenylindoleCD8+ T cellsIRE1αSmall interfering RNAshort hairpin RNAROSsiRNAinositol-requiring enzyme 1αOxidative stressendoplasmic reticulumeukaryotic initiation factor 2αnuclear factor κBUnfolded protein responseX-box binding protein 1PERKReactive oxygen species
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Authors
Shuli MD, PhD, Guannan MD, PhD, Yuqi MS, Zhe MD, PhD, Sen MS, Wei MD, PhD, Qiong MD, PhD, Rui MD, PhD, Jingjing MS, Ling MD, PhD, Kai MD, PhD, Qi MD, PhD, Gang MD, PhD, Tianwen MD, PhD, Chunying MD, PhD,