Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation

Article ID	Journal	Published Year	Pages	File Type
5646606	Journal of Allergy and Clinical Immunology	2017	14 Pages	PDF

Keywords

GOF IC50 IFN-γ ATG Tc1 TH17 cell ICOS TFH anti-thymocyte globulin Janus kinase BSA Ruxolitinib STAT Gain of function autoimmunity body surface area Th1 cell Signal transducer and activator of transcription Programmed death half-maximal inhibitory concentration JAK Inducible costimulator

Related Topics

Life Sciences Immunology and Microbiology Immunology

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Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation

Authors

Katja G. MD, PhD, Louis-Marie PhD, Fayhan MD, Ashley MD, Qi PhD, Hao PhD, Clement PhD, Troy R. MD, PhD, Sergio D. MD, PhD, Thomas A. MD, Luigi D. MD, Imelda C. MD, Lisa R. MD, Talal A. MD, MSc,