MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2

Article ID	Journal	Published Year	Pages	File Type
5646725	Journal of Allergy and Clinical Immunology	2017	14 Pages	PDF

Keywords

CMU pAkt OVA SSI SPG HDAC AAD RSV Chlamydia muridarum DEX AHR PI3K DMSO PI3 kinase Severe asthma STAT Influenza Ovalbumin miR-21 allergic airway disease Chronic obstructive pulmonary disease COPD Dexamethasone Dimethyl sulfoxide Flu phosphatase and tensin homolog phosphorylated Akt phosphoinositide 3-kinase Signal transducer and activator of transcription MicroRNA MiRNA Haemophilus influenzae histone deacetylase Histone deacetylase 2 Respiratory syncytial virus Airway hyperresponsiveness Pten Corticosteroids glucocorticoid receptor

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Life Sciences Immunology and Microbiology Immunology

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MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2

Authors

Richard Y. PhD, Jay C. PhD, James W. B Biomed Sci, Malcolm R. PhD, Ama T. PhD, Jemma R. B Biomed Sci, Prema M. B Biomed Sci, Nicole G. PhD, Bernadette BSc, Tatt Jhong B Biomed Sci, Krishna P. MSc, Thi Hiep MSc, Andrew G. PhD, Simon PhD, Joerg MD, PhD,