| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5647015 | Journal of Allergy and Clinical Immunology | 2016 | 15 Pages |
Abstract
Our novel findings suggest that platelets might be important cellular sources of IL-33 protein in vivo and that platelet-derived IL-33 might play a role in airway inflammation. Therefore platelets might become an attractive novel therapeutic target for asthma and probably allergic inflammation.
Keywords
MDCIL1RL1HMVEC-LILC2IL-33BALHBSSOVAqPCRMIPGAPDHQuantitative PCRAsthmaEosinophilAirway inflammationOvalbuminthymus and activation-regulated chemokineTARCGroup 2 innate lymphoid cellbronchoalveolar lavageAlveolar macrophagePapainmacrophage inflammatory proteinPlateletMacrophage-derived chemokineglyceraldehyde-3-phosphate dehydrogenase
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Authors
Tomohiro PhD, Hirotoshi MD, PhD, Hideaki MD, PhD, Kyoko MD, PhD, Maiko PhD, Ken PhD, Tetsuo MD, PhD, Naoko PhD, Arisa PhD, Eisuke PhD, Hiroshi MD, PhD, Susumu PhD, Hirohisa MD, PhD, Kenji MD, PhD, Akio PhD,