Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5647058 | Journal of Allergy and Clinical Immunology | 2017 | 50 Pages |
Abstract
AD is a heterogeneous disease both clinically and biologically. Four distinct clusters of patients with AD have been identified that could represent endotypes with unique biological mechanisms. Elucidation of these endotypes warrants further investigation and will require future intervention trials with specific agents, such as biologics.
Keywords
disease heterogeneitypulmonary and activation-regulated chemokineGRO-αISACsCD14TIMP-1PARCTSLPBSAPCAEndotypestissue inhibitor of metalloproteinases 1thymus and activation-regulated chemokinePrincipal component analysisClustersAtopic dermatitisTARCbody surface areaVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)PhenotypesThymic stromal lymphopoietinSoluble CD14Personalized medicine
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Authors
Judith L. MD, Ian PhD, Carla A.F.M. MD, PhD, Stefan PhD, Barbara PhD, Eszter PhD, Bret R. PhD, Tomas MD, PhD, Matthew A. PhD, Marjolein S. MD, PhD, Athula PhD, Julia PhD, Richard D. PhD, DirkJan MD, PhD,