Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice

Article ID	Journal	Published Year	Pages	File Type
5647127	Journal of Allergy and Clinical Immunology	2017	13 Pages	PDF

Abstract

These results suggest that TACI A181E heterozygosity results in TACI haploinsufficiency with increased susceptibility to pneumococcal infection. This has important implications for asymptomatic TACI A181E carriers.

Keywords

NF-κB CRD CVID TNFR TACI Natural antibodies APRIL BAFF cysteine-rich domain nuclear factor κB wild-type Common variable immunodeficiency TNF receptor a proliferation-inducing ligand

Related Topics

Life Sciences Immunology and Microbiology Immunology

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Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice

Authors

Haifa H. BSc, John J. MD, Erin MD, PhD, Sumana MS, Kyriaki PhD, Lilit MD, PhD, Halli BS, Tatyana BS, Richard MD, PhD, Lennart MD, Anthony C. BS, Richard MD, PhD, John MD, Richard MD, Raif S. MD,