Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5647695 | Journal of the American Academy of Dermatology | 2017 | 12 Pages |
Abstract
The reported prevalence of nevus-associated melanoma varies substantially. We performed a systematic review and meta-analysis to determine the incidence and prevalence of this disease; we also performed subanalyses considering age, tumor thickness, and nevus-type classification. In 38 observational cohort and case-control studies, 29.1% of melanomas likely arose from a preexisting nevus and 70.9% de novo. Any given melanoma was 64% less likely to be nevus-associated than de novo (risk ratio 0.36, 95% confidence interval [CI] 0.29-0.44; PÂ <Â .001; I2Â =Â 99%); nevus-associated melanomas had a lower mean Breslow thickness than de novo melanomas (mean difference -0.39Â mm; 95% CI -0.60 to -0.18; PÂ =Â .0003; I2Â =Â 66%). No significant differences were noted regarding the association of nevus-associated melanomas with nondysplastic nevi or dysplastic nevi (risk ratio 0.77, 95% CI 0.49-1.20; PÂ =Â .24; I2Â =Â 98%).
Keywords
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Dermatology
Authors
Riccardo MD, Athanassios MD, Aimilios MD, Elvira MD, Giuseppe MD, Caterina MD, PhD,