| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5648885 | Journal of Dermatological Science | 2017 | 27 Pages |
Abstract
In this review, we highlight the most relevant findings regarding the involvement of innate immune cells during the early stage of cutaneous fibrosis in SSc, with emphasis on the role of neutrophils, myeloid cells and innate lymphoid/NK cells in the pathogenesis of SSc and their potential as therapeutic targets for this difficult-to-treat autoimmune disease.
Keywords
ILCLMPPLipopolysacharideECMRNSGMPSSCLPSMMPROSsiRNAsmooth muscle actinsystemic sclerosisInnate immunityneutrophil extracellular trapalternativeNETSMANK cellinnate lymphoid cellMyeloid cellsExtracellular matrixMatrix metalloproteasesMacrophageneutrophilCollagenreactive nitrogen speciesReactive oxygen species
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Authors
Verena Raker, Jessica Haub, Ana Stojanovic, Adelheid Cerwenka, Detlef Schuppan, Kerstin Steinbrink,