Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5648892 | Journal of Dermatological Science | 2017 | 28 Pages |
Abstract
We show that Scurfy mice show a predominant AC-5 ANA pattern typical for mixed connective tissue disease as in scleroderma. The autoimmune inflammation in scurfy skin mainly consists of CD4+ T cells with Th2 differentiation and alternatively-activated (M2) macrophages as it is found in scleroderma with advanced fibrosis.
Keywords
Related Topics
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Dermatology
Authors
Stefanie Haeberle, Verena Raker, Jessica Haub, Yong O. Kim, Shih-Yen Weng, Osman K. Yilmaz, Alexander Enk, Kerstin Steinbrink, Detlef Schuppan, Eva N. Hadaschik,