| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5648904 | Journal of Dermatological Science | 2017 | 8 Pages |
Abstract
The modified IFN-γ ELISpot using activated PBMCs was more sensitive than the conventional IFN-γ ELISpot was for detecting drug-induced IFN-γ production, which could be a useful in vitro tool for identifying culprit drugs in cADR cases.
Keywords
MPECADRMaculopapular exanthemaDIHSdlSTDrug-induced lymphocyte stimulation testSJSELISPOTPBMCsPHAPhytohemagglutininLTTOVAIFN-γerythema multiformeOvalbuminEnzyme-linked immunospotDrug rash with eosinophilia and systemic symptomslymphocyte transformation testDrug hypersensitivitytenperipheral blood mononuclear cellsStevens-Johnson syndromedrug-induced hypersensitivity syndromeDRESSToxic epidermal necrolysisCutaneous adverse drug reactions
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Authors
Kenichi Kato, Asami Kawase, Hiroaki Azukizawa, Takaaki Hanafusa, Yukinobu Nakagawa, Hiroyuki Murota, Shimon Sakaguchi, Hideo Asada, Ichiro Katayama,