| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5649119 | Journal of Dermatological Science | 2017 | 38 Pages |
Abstract
These results demonstrate a H2O2-involved autoimmune phenotype in vitiligo and halo nevus, characterized by increased level of IFN-γ-inducible chemokine pair CXCL10-CXCR3, as well as a dense CD8+ T infiltration in the skin lesions, thus suggesting a similar pathogenesis of the two diseases.
Keywords
FBSqRT-PCRIFN-γPBMCsCXCLCCRCXCL10CXCR3FACSPBSCXCRhalo nevusCD8+ T cellsROSHydrogen peroxideinterferon-gammaFlow Cytometry Analysisanalysis of varianceANOVAEnzyme-linked immunosorbent assayELISAOxidative stresstumor necrosis factor-αfetal bovine serumperipheral blood mononuclear cellsTNF-αCXC chemokine ligandphosphate buffer solutionH2O2quantitative real-time PCRvitiligoReactive oxygen speciesCXC chemokine receptorCC chemokine receptor
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Authors
Yuqi Yang, Shuli Li, Guannan Zhu, Qian Zhang, Gang Wang, Tianwen Gao, Chunying Li, Lin Wang, Zhe Jian,