Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5649147 | Journal of Investigative Dermatology | 2017 | 29 Pages |
Abstract
Data from in vitro experiments suggest that vitamin D reduces the rate of skin aging, whereas population studies suggest the opposite, most likely due to confounding by UV exposure. We investigated whether there are causal associations between 25-hydroxyvitamin D concentrations and features of skin aging in a bidirectional Mendelian randomization study. In the Rotterdam Study (N = 3,831; 58.2% women, median age 66.5 years) and Leiden Longevity Study (N = 661; 50.5% women, median age 63.1 years), facial skin aging features (perceived age, wrinkling, pigmented spots) were assessed either manually or digitally. Associations between 25-hydroxyvitamin D and skin aging features were tested by multivariable linear regression. Mendelian randomization analyses were performed using single nucleotide polymorphisms identified from previous genome-wide association studies. After meta-analysis of the two cohorts, we observed that higher serum 25-hydroxyvitamin D was associated with a higher perceived age (P-value = 3.6 à 10-7), more skin wrinkling (P-value = 2.6 à 10-16), but not with more pigmented spots (P-value = 0.30). In contrast, a genetically determined 25-hydroxyvitamin D concentration was not associated with any skin aging feature (P-values > 0.05). Furthermore, a genetically determined higher degree of pigmented spots was not associated with higher 25-hydroxyvitamin D (P-values > 0.05). Our study did not indicate that associations between 25-hydroxyvitamin D and features of skin aging are causal.
Related Topics
Health Sciences
Medicine and Dentistry
Dermatology
Authors
Raymond Noordam, Merel A. Hamer, Luba M. Pardo, Tamara van der Nat, Jessica C. Kiefte-de Jong, Manfred Kayser, P Eline Slagboom, André Uitterlinden, M. Carola Zillikens, Marian Beekman, Tamar Nijsten, Diana van Heemst, David A. Gunn,