Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5649326 | Journal of Investigative Dermatology | 2017 | 8 Pages |
Abstract
Extracellular vesicles (exosomes, microvesicles, and apoptotic bodies) are ubiquitous in human tissues, circulation, and body fluids. Of these vesicles, exosomes are of growing interest among investigators across multiple fields, including dermatology. The characteristics of exosomes, their associated cargo (nucleic acids, proteins, and lipids), and downstream functions are vastly different, depending on the cell origin. Here, we review concepts in extracellular vesicle biology, with a focus on exosomes, highlighting recent studies in the field of dermatology. Furthermore, we highlight emerging technical issues associated with isolating and measuring exosomes. Extracellular vesicles, including exosomes, have immediate potential for serving as biomarkers and therapeutics in dermatology over the next decade.
Keywords
Related Topics
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Medicine and Dentistry
Dermatology
Authors
Jeffrey D. McBride, Luis Rodriguez-Menocal, Evangelos V. Badiavas,