Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5649776 | Journal of Investigative Dermatology | 2017 | 7 Pages |
Abstract
Skin is the primary barrier between the body and the outside world, functioning not only as a physical barrier, but also as an immunologic first line of defense. A large number of T cells populate the skin. This review highlights the ability of these cutaneous T cells to regulate skin-specific environmental threats, including microbes, injuries, solar UV radiation, and allergens. Since much of this knowledge has been advanced from murine studies, we focus our review on how the mouse state has informed the human state, emphasizing the key parallels and differences.
Keywords
Related Topics
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Medicine and Dentistry
Dermatology
Authors
Jutamas Suwanpradid, Zachary E. Holcomb, Amanda S. MacLeod,