Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5654200 | Journal of Orthopaedics | 2017 | 7 Pages |
Abstract
Perivascular soft tissue tumors are relatively uncommon neoplasms of unclear line of differentiation, although most are presumed to originate from pericytes. Previously, we reported a shared immunophenotype across these related tumor types. Here, we extend these findings to examine the expression of the pericyte markers angiopoietin-1 and -2 (Ang-1 and -2) among perivascular soft tissue tumors. Results showed consistent Ang-2 but not Ang-1 expression across tumor types. In summary, the absence of Ang-1 expression distinguishes perivascular from vascular soft tissue tumors. Ang-2 expression is present across perivascular soft tissue tumors, with some variation between histologic subtypes.
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Authors
Swati Shrestha, Jia Shen, Paulina Giacomelli, Michelle A. Scott, Chia Soo, Kang Ting, Bruno Péault, Sarah M. Dry, Aaron W. James,