| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5654512 | Best Practice & Research Clinical Gastroenterology | 2017 | 9 Pages |
Abstract
The demand of donor livers for transplantation exceeds the supply. In an attempt to maximize the number of potentially usable donor livers, several centers are exploring the role of machine perfusion. This review provides an update on machine perfusion strategies and basic concepts, based on current clinical issues, and discuss challenges, including currently used biomarkers for assessing the quality and viability of perfused organs. The potential benefits of machine perfusion on immunogenicity and the consequences on post-operative immunosuppression management are discussed.
Keywords
DCDRIPCHIFSECTLR-4IPCNACMPTN-acetylcysteineischemic preconditioningROSAktHOPEDonation after Circulatory DeathPreservationoxygen free radicalsKupffer cellsSinusoidal endothelial cellsendoplasmic reticulumHypoxia-inducible factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Model of End Stage Liver DiseaseNormothermicNitric oxideheme oxygenaseHypothermicMachine perfusionRemote ischemic preconditioningLiver transplantationMELD
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Authors
Jasmijn MD, Andrea (Senior Clinical Fellow), Jeroen MD, PhD, Philipp (Professor),