| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5654826 | Clinical Immunology | 2017 | 9 Pages |
Abstract
We demonstrate that a majority of DN T cells exhibits effector memory phenotypes, express IFN-γ, and fail to proliferate. DN T cells from psoriasis patients are characterized by reduced DNA methylation of the IFNG gene and increased PD-1 expression. Furthermore, PD-1 positive DN T cells infiltrate the epidermis in psoriatic skin lesions. Our observations offer additional insight into the molecular pathophysiology of plaque psoriasis and show promise as potential disease biomarkers and/or therapeutic targets for future interventions.
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Authors
D. Brandt, M. Sergon, S. Abraham, K. Mäbert, C.M. Hedrich,